Département de biochimie
Dr. Jurgen Sygusch
Professeur titulaire
research| publication| contact
Research Statement/ Interêts de Recherche
The goal of our laboratory is to understand how proteins and enzymes function at the molecular level and then to translate this knowledge to specifically inhibit the function of these macromolecules in disease.

L'enjeu de notre laboratoire est de comprendre le fonctionnement des protéines et des enzymes au niveau moléculaire et d'appliquer ces informations afin d'inhiber spécifiquement la fonction de ces macromolécules dans des maladies.

Academic Profile
Research complement: 6 graduate students (5 PhD level), 1 research technician, 1 senior research associate (contractual); summer students are welcome

Teaching: Enzymology & Structural Biology

Coordination: Professional Masters program

Committees: NSERC GSC 32 2005-2008; Microgravity Discipline Working Group 2008-2010; Head - Professional Masters program; Departmental

Research funding: NSERC/CRSNG; CIHR/IRSC; CSA/ASC; Univalor; Ministère de Développement économique, de l'Innovation et de l'Exportation (Québec)

Cours/Courses
Publications
de la Paz Santangelo M, Gest PM, Guerin ME, Coinçon M, Pham H, Ryan G, Puckett SE, Spencer JS, Gonzalez-Juarrero M, Daher R, Lenaerts AJ, Schnappinger D, Therisod M, Ehrt S, Sygusch J, Jackson M. (2011) Glycolytic and Non-glycolytic Functions of Myco-bacterium tuberculosis Fructose-1,6-bis-phosphate Aldolase, an Essential Enzyme Produced by Replicating and Non-replicating Bacilli. J Biol Chem. 286(46): 40219-31.
Gabin CMB, Arthus-Cartier G, Hannaert V, Thérisod H, Sygusch J*. Thérisod M*. (2011) Mannitol based inhibitors of fructose 1,6-bisphosphate Schiff-base forming aldolase from Trypanosoma brucei. ACS Med. Chem. Lett., 2 (11), 804–808. *Corresponding co-author
3 Cappadocia L, Parent JS, Zampini E, Lepage E, Sygusch J*, Brisson N. (2012) A conserved lysine residue of plant Whirly proteins is necessary for higher order protein assembly and protection against DNA damage. Nucleic Acids Res. 40(1):258-69 *Corresponding co-author

Patents
“High-resolution fast quantitative docking using frequency domain correlation techniques” Blom NS, Sygusch J. US patent No. 5,866,343.
“Protein Crystallization in Microfluidic Structures” Weigl B, Sygusch J. US patent No. 6,409,832B2.
“Plant transcriptional activator and uses thereof”. Brisson, N., Desveaux, D., Subramaniam, R. and Sygusch, J. Provisional patent No. 10662-121USPR.
"Nouveaux composés aromatiques inhibiteurs des aldolases, procédé de synthèse et applications". Dax C, Azéma L, Sygusch J, Blonski C. France, PCT/FR 2004/001664.
Contacts
Mailing
Dr. Jurgen Sygusch
Professeur titulaire
Biochimie/Médecine
Université de Montréal
CP 6128, Station Centre-Ville
Montréal, QC Canada
H3C 3J7

Courier and shipping
Dr. Jurgen Sygusch
Biochimie/Médecine
Université de Montréal
Pavillon Roger Gaudry, D-347
2900 Boul. Edouard-Montpetit
Montréal, QC Canada
H3T 1J4

Téléphone: +1(514)343-2389
FAX: +1(514)343-6463 / 343-2210

Jurgen.Sygusch@UMontreal.CA